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NCT01595581, REGISTRATION: May 8, 2012. testosterone.
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Gruplar arasında demografik özellikler bakımından fark yoktu. Östrojen düzeyi ve testosteron düzeyleri PKOS olan hastalarda daha yüksek bulundu (41,12±13,59 ve 35,57±19,29 pg/mL, p=0,09, 105±58,5 ve 17,6±10,9 ng/dL, p=0,01, sırasıyla). PKOS olan hastalarda maksimum QTc süresi daha uzun (436,3±30,2 ve 420,9±21,9 ms, p=0,05), QT dispersiyonu anlamlı olarak daha fazla bulundu (47,1 ve 32,7 ms, p=0,01). Serum insülin düzeyi ile maksimum (r=0,341, p=0,033), minimum (r=0,402, p=0,011) ve ortalama (r=0,337, p=0,036) QTc süreleri arasında pozitif korelasyon bulundu. Serum östrojen ve testosteron düzeyleri ile QT dispersiyonunun korele olduğu saptandı (sırasıyla r=0,326, p=0,046 ve r=0,525, p=0,001). SONUÇ: Bu çalışmamız PKOS olan genç kadınlarda QT dispersiyonunun arttığını ve östrojen, testosteron ve insülin düzeylerinin QT süresi üzerine etkileri olduğunu göstermiştir. testosterone.
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Microarray and qRT-PCR were used to investigate circulating miRNAs in PCOS during clinical diagnosis. The targets of dys-regulated miRNAs were predicted using bioinformatics, followed by function and pathway analysis using the databases of Gene Ontology and the KEGG pathway. testosterone.
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Fifty-four participants were randomly enrolled into this study. Basal plasma testosterone levels were measured between 8:30 am and 10 am. After 24 hours of blood drawing, each subject completed personality questionnaires. testosterone.
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We investigated 134 non-diabetic, middle-aged, hypertensive men and 60 age-matched normotensive males. All participants were subject to measurement of aortic systolic (aoSBP) and pulse pressure (aoPP) by pulse wave analysis using the SphygmoCor device. Wave reflections were assessed by the measurement of heart rate corrected augmentation index (AIx75). Echocardiography was performed in all individuals and left ventricular mass (LVM) was calculated using the Devereux’s formula. Plasma TT was measured by enzyme immunoassay. testosterone.
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Momordica charantia (M. charantia) seed has been supposed to have an antifertility property but mechanisms underlying the infertility effect have not been investigated. testosterone.
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